Assay Detail
Functional
CHEMBL3616315
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Antitubercular activity against fluorescent reporter strain of Mycobacterium tuberculosis H37Rv after 5 days by fluorescence assay
15
Total Activities
5
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mycobacterium tuberculosis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of Pyrazolo[1,5-a]pyridine-3-carboxamides as Novel Antitubercular Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| MIC | 5 | - | - |
| IC50 | 5 | 8.28 | 8.60 |
| IC90 | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3612953 | — | — | 3 | 8.60 |
| CHEMBL3612958 | — | — | 3 | 8.60 |
| CHEMBL374478 | RIFAMPIN | 4.0 | 3 | 8.39 |
| CHEMBL3612954 | — | — | 3 | 8.29 |
| CHEMBL3612967 | — | — | 3 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3612953 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL3612958 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL374478 | RIFAMPIN | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL3612954 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL3612967 | — | IC50 | = | 31.3 | nM | 7.50 |
| CHEMBL3612953 | — | MIC | = | 6.3 | nM | - |
| CHEMBL3612954 | — | MIC | = | 11.0 | nM | - |
| CHEMBL3612958 | — | MIC | = | 5.6 | nM | - |
| CHEMBL3612967 | — | MIC | = | 129.0 | nM | - |
| CHEMBL374478 | RIFAMPIN | MIC | = | 6.5 | nM | - |
| CHEMBL3612953 | — | IC90 | = | 6.5 | nM | - |
| CHEMBL3612954 | — | IC90 | = | 12.0 | nM | - |
| CHEMBL3612958 | — | IC90 | = | 5.7 | nM | - |
| CHEMBL3612967 | — | IC90 | = | 150.0 | nM | - |
| CHEMBL374478 | RIFAMPIN | IC90 | = | 6.9 | nM | - |