Assay Detail
Functional
CHEMBL3618845
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human muscarinic M4 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M4 (CHEMBL1821) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M₁ agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 6.42 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL667 | ACETYLCHOLINE | 4.0 | 1 | 7.31 |
| CHEMBL3616504 | — | — | 1 | 6.95 |
| CHEMBL3618440 | — | — | 1 | 6.94 |
| CHEMBL134641 | SABCOMELINE | 2.0 | 1 | 6.67 |
| CHEMBL3618445 | — | — | 1 | 6.64 |
| CHEMBL21536 | XANOMELINE | 4.0 | 1 | 6.64 |
| CHEMBL3616499 | — | — | 1 | 6.63 |
| CHEMBL3618444 | — | — | 1 | 6.45 |
| CHEMBL3618449 | — | — | 1 | 6.41 |
| CHEMBL3616500 | — | — | 1 | 6.41 |
| CHEMBL3618450 | — | — | 1 | 6.39 |
| CHEMBL2111051 | TALSACLIDINE | 2.0 | 1 | 6.07 |
| CHEMBL3616501 | — | — | 1 | 5.97 |
| CHEMBL3618436 | — | — | 1 | 5.96 |
| CHEMBL3616497 | — | — | 1 | 5.87 |
| CHEMBL3618447 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL667 | ACETYLCHOLINE | EC50 | = | 48.8 | nM | 7.31 |
| CHEMBL3616504 | — | EC50 | = | 113.0 | nM | 6.95 |
| CHEMBL3618440 | — | EC50 | = | 115.0 | nM | 6.94 |
| CHEMBL134641 | SABCOMELINE | EC50 | = | 214.0 | nM | 6.67 |
| CHEMBL3618445 | — | EC50 | = | 227.0 | nM | 6.64 |
| CHEMBL21536 | XANOMELINE | EC50 | = | 229.0 | nM | 6.64 |
| CHEMBL3616499 | — | EC50 | = | 235.0 | nM | 6.63 |
| CHEMBL3618444 | — | EC50 | = | 355.0 | nM | 6.45 |
| CHEMBL3618449 | — | EC50 | = | 392.0 | nM | 6.41 |
| CHEMBL3616500 | — | EC50 | = | 393.0 | nM | 6.41 |
| CHEMBL3618450 | — | EC50 | = | 405.0 | nM | 6.39 |
| CHEMBL2111051 | TALSACLIDINE | EC50 | = | 844.0 | nM | 6.07 |
| CHEMBL3616501 | — | EC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL3618436 | — | EC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL3616497 | — | EC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL3618447 | — | EC50 | = | 3720.0 | nM | 5.43 |