Assay Detail
Binding
CHEMBL3619484
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ERCC1-XPF (unknown origin) by high-throughput fluorescence based in-vitro endonuclease assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
DNA excision repair protein ERCC-1/DNA repair endonuclease XPF (CHEMBL3883316) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.38 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3617281 | — | — | 1 | 6.30 |
| CHEMBL3617205 | — | — | 1 | 6.22 |
| CHEMBL3617209 | — | — | 1 | 6.22 |
| CHEMBL3617207 | — | — | 1 | 6.16 |
| CHEMBL3617284 | — | — | 1 | 6.16 |
| CHEMBL3617286 | — | — | 1 | 6.10 |
| CHEMBL3617282 | — | — | 1 | 6.10 |
| CHEMBL3617283 | — | — | 1 | 6.10 |
| CHEMBL223338 | — | — | 1 | 6.00 |
| CHEMBL3617285 | — | — | 1 | 6.00 |
| CHEMBL182381 | — | — | 1 | 5.82 |
| CHEMBL3617203 | — | — | 1 | 5.82 |
| CHEMBL3617287 | — | — | 1 | 5.77 |
| CHEMBL361011 | — | — | 1 | 5.75 |
| CHEMBL3617206 | — | — | 1 | 5.57 |
| CHEMBL181653 | — | — | 1 | 5.54 |
| CHEMBL361350 | — | — | 1 | 5.41 |
| CHEMBL3617197 | — | — | 1 | 5.41 |
| CHEMBL440562 | — | — | 1 | 5.41 |
| CHEMBL216874 | — | — | 1 | 5.38 |
| CHEMBL3617208 | — | — | 1 | 5.34 |
| CHEMBL3617199 | — | — | 1 | 5.21 |
| CHEMBL3617288 | — | — | 1 | 5.20 |
| CHEMBL3617200 | — | — | 1 | 5.19 |
| CHEMBL3617201 | — | — | 1 | 5.18 |
| CHEMBL3617291 | — | — | 1 | 5.16 |
| CHEMBL3617289 | — | — | 1 | 5.08 |
| CHEMBL3617198 | — | — | 1 | 5.04 |
| CHEMBL1415852 | — | — | 1 | 4.92 |
| CHEMBL3617204 | — | — | 1 | 4.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3617281 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3617205 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3617209 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3617207 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3617284 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3617286 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3617282 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3617283 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL223338 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3617285 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3617203 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL182381 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3617287 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL361011 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3617206 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL181653 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL361350 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3617197 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL440562 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL216874 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL3617208 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3617199 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL3617288 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL3617200 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL3617201 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL3617291 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL3617289 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL3617198 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL1415852 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3617204 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL183852 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL3617290 | — | IC50 | = | 25300.0 | nM | 4.60 |
| CHEMBL187010 | — | IC50 | = | 27300.0 | nM | 4.56 |
| CHEMBL1207029 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL366051 | — | IC50 | = | 48800.0 | nM | 4.31 |
| CHEMBL182974 | — | IC50 | = | 80400.0 | nM | 4.09 |
| CHEMBL3617202 | — | IC50 | = | 96200.0 | nM | 4.02 |
| CHEMBL183018 | — | IC50 | > | 100000.0 | nM | - |