Assay Detail
Functional
CHEMBL3619935
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human LoVo/DX cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LoVo/DX |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Anti-proliferative activity of Monensin and its tertiary amide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.29 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL256105 | MONENSIN | 4.0 | 1 | 6.21 |
| CHEMBL3617685 | — | — | 1 | 5.42 |
| CHEMBL3617680 | — | — | 1 | 5.33 |
| CHEMBL3617684 | — | — | 1 | 5.31 |
| CHEMBL3617681 | — | — | 1 | 5.21 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.17 |
| CHEMBL3617682 | — | — | 1 | 5.00 |
| CHEMBL3617683 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL256105 | MONENSIN | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL3617685 | — | IC50 | = | 3780.0 | nM | 5.42 |
| CHEMBL3617680 | — | IC50 | = | 4630.0 | nM | 5.33 |
| CHEMBL3617684 | — | IC50 | = | 4860.0 | nM | 5.31 |
| CHEMBL3617681 | — | IC50 | = | 6090.0 | nM | 5.21 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 6730.0 | nM | 5.17 |
| CHEMBL3617682 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL3617683 | — | IC50 | = | 20650.0 | nM | 4.68 |