Assay Detail
Binding
CHEMBL3619994
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human activated-MMP1 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as fluorogenic substrate incubated for 4 hrs followed by substrate addition measured every 10 secs for 20 mins by fluorometric assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.05 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3617407 | — | — | 1 | 6.70 |
| CHEMBL3617402 | — | — | 1 | 6.55 |
| CHEMBL3617401 | — | — | 1 | 6.50 |
| CHEMBL3617404 | — | — | 1 | 6.18 |
| CHEMBL3617400 | — | — | 1 | 6.11 |
| CHEMBL3617403 | — | — | 1 | 5.89 |
| CHEMBL3617405 | — | — | 1 | 5.85 |
| CHEMBL3617406 | — | — | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3617407 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3617402 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3617401 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3617404 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL3617400 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL3617403 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3617405 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3617406 | — | IC50 | = | 26000.0 | nM | 4.58 |