Assay Detail
Binding
CHEMBL3620254
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Binding affinity to Lymnaea stagnalis AChBP after 300 seconds by SPR biosensor analysis
8
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Lymnaea stagnalis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploration of the molecular architecture of the orthosteric binding site in the α4β2 nicotinic acetylcholine receptor with analogs of 3-(dimethylamino)butyl dimethylcarbamate (DMABC) and 1-(pyridin-3-yl)-1,4-diazepane.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 6.80 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3616577 | — | — | 2 | 7.70 |
| CHEMBL3616575 | — | — | 2 | 6.80 |
| CHEMBL3 | NICOTINE | 4.0 | 2 | 6.50 |
| CHEMBL122270 | LOBELINE | 2.0 | 2 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3616577 | — | Kd | = | 20.0 | nM | 7.70 |
| CHEMBL3616577 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL3616575 | — | Kd | = | 160.0 | nM | 6.80 |
| CHEMBL3616575 | — | Kd | = | 158.49 | nM | 6.80 |
| CHEMBL3 | NICOTINE | Kd | = | 320.0 | nM | 6.50 |
| CHEMBL3 | NICOTINE | Kd | = | 316.23 | nM | 6.50 |
| CHEMBL122270 | LOBELINE | Kd | = | 630.0 | nM | 6.20 |
| CHEMBL122270 | LOBELINE | Kd | = | 630.96 | nM | 6.20 |