Assay Detail
Binding
CHEMBL3620652
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Inhibition of CYP26A1 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of amide imidazole derivatives as novel metabolic enzyme CYP26A1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.06 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1766005 | — | — | 1 | 8.52 |
| CHEMBL224305 | — | — | 1 | 8.40 |
| CHEMBL3617993 | — | — | 1 | 8.00 |
| CHEMBL180856 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1766005 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL224305 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3617993 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL180856 | — | IC50 | = | 50.0 | nM | 7.30 |