Assay Detail
Binding
CHEMBL3624101
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Inhibition of LIMK1 in human ZR75-1 cells assessed as inhibition of cofilin phosphorylation after 5 hrs
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | ZR-75-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery, Development, and SAR of Aminothiazoles as LIMK Inhibitors with Cellular Anti-Invasive Properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.54 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3623438 | — | — | 1 | 6.22 |
| CHEMBL3623441 | — | — | 1 | 6.10 |
| CHEMBL3623440 | — | — | 1 | 5.85 |
| CHEMBL3623435 | — | — | 1 | 5.82 |
| CHEMBL3623443 | — | — | 1 | 5.70 |
| CHEMBL3623437 | — | — | 1 | 5.68 |
| CHEMBL3622873 | — | — | 1 | 5.66 |
| CHEMBL3622874 | — | — | 1 | 5.60 |
| CHEMBL3622867 | — | — | 1 | 5.42 |
| CHEMBL3623439 | — | — | 1 | 5.18 |
| CHEMBL3623436 | — | — | 1 | 5.04 |
| CHEMBL3622871 | — | — | 1 | 4.94 |
| CHEMBL3623434 | — | — | 1 | 4.85 |
| CHEMBL3623433 | — | — | 1 | - |
| CHEMBL3622875 | — | — | 1 | - |
| CHEMBL3622872 | — | — | 1 | - |
| CHEMBL3622870 | — | — | 1 | - |
| CHEMBL3622869 | — | — | 1 | - |
| CHEMBL3623442 | — | — | 1 | - |
| CHEMBL3622868 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3623438 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3623441 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3623440 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3623435 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3623443 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3623437 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3622873 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3622874 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3622867 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL3623439 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL3623436 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL3622871 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL3623434 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3623433 | — | IC50 | - | — | - | |
| CHEMBL3622875 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3622872 | — | IC50 | - | — | - | |
| CHEMBL3622870 | — | IC50 | - | — | - | |
| CHEMBL3622869 | — | IC50 | - | — | - | |
| CHEMBL3623442 | — | IC50 | - | — | - | |
| CHEMBL3622868 | — | IC50 | - | — | - |