Assay Detail
Binding
CHEMBL3624233
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-DHT from androgen receptor in human MDA-MB-453 cells after 90 mins by TopCount analysis
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of BMS-641988, a Novel Androgen Receptor Antagonist for the Treatment of Prostate Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.83 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3623125 | — | — | 1 | 9.00 |
| CHEMBL3623127 | — | — | 1 | 8.77 |
| CHEMBL3623126 | — | — | 1 | 8.70 |
| CHEMBL3623119 | — | — | 1 | 8.52 |
| CHEMBL3623122 | — | — | 1 | 8.15 |
| CHEMBL3623114 | — | — | 1 | 8.10 |
| CHEMBL3623124 | — | — | 1 | 8.00 |
| CHEMBL3623123 | — | — | 1 | 7.92 |
| CHEMBL3623116 | — | — | 1 | 7.64 |
| CHEMBL3623118 | — | — | 1 | 7.51 |
| CHEMBL3623121 | — | — | 1 | 7.51 |
| CHEMBL3623117 | — | — | 1 | 7.30 |
| CHEMBL3623120 | — | — | 1 | 7.30 |
| CHEMBL409 | BICALUTAMIDE | 4.0 | 1 | 7.19 |
| CHEMBL3623115 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3623125 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL3623127 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL3623126 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL3623119 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL3623122 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL3623114 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL3623124 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL3623123 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL3623116 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL3623118 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL3623121 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL3623117 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL3623120 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL409 | BICALUTAMIDE | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL3623115 | — | Ki | = | 1600.0 | nM | 5.80 |