Assay Detail
Binding
CHEMBL3624709
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Inhibition of KDM4C (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.83 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1230640 | — | — | 1 | 6.20 |
| CHEMBL1982368 | — | — | 1 | 6.00 |
| CHEMBL316034 | — | — | 1 | 5.60 |
| CHEMBL3621850 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1230640 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL1982368 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL316034 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL3621850 | — | IC50 | = | 3162.28 | nM | 5.50 |