Assay Detail
Binding
CHEMBL3624713
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Inhibition of KDM5C (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.33 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL316034 | — | — | 1 | 6.30 |
| CHEMBL90852 | N-OXALYLGLYCINE | — | 1 | 5.10 |
| CHEMBL1230640 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL316034 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL90852 | N-OXALYLGLYCINE | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL1230640 | — | IC50 | = | 25118.86 | nM | 4.60 |