Assay Detail
Binding
CHEMBL3625035
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIF1 in human HEK293T cells transfected with pGL3-5HRE-VEGF and pRL-SV40 after 24 hrs by dual luciferase reporter assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha (CHEMBL2221345) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.23 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2021442 | MANASSANTIN A | — | 1 | 7.96 |
| CHEMBL3105545 | — | — | 1 | 6.50 |
| CHEMBL3623807 | — | — | 1 | 6.46 |
| CHEMBL3623808 | — | — | 1 | 6.42 |
| CHEMBL3623806 | — | — | 1 | 6.37 |
| CHEMBL3623812 | — | — | 1 | 6.23 |
| CHEMBL3623811 | — | — | 1 | 6.16 |
| CHEMBL3623805 | — | — | 1 | 6.04 |
| CHEMBL3623810 | — | — | 1 | 5.84 |
| CHEMBL3623809 | — | — | 1 | 5.71 |
| CHEMBL3623803 | — | — | 1 | 5.68 |
| CHEMBL3621232 | — | — | 1 | 5.43 |
| CHEMBL3623804 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2021442 | MANASSANTIN A | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3105545 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3623807 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3623808 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL3623806 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL3623812 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL3623811 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3623805 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL3623810 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL3623809 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL3623803 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL3621232 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL3623804 | — | IC50 | > | 10000000.0 | nM | - |