Assay Detail
Binding
CHEMBL3625155
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Inhibition of EGFR (unknown origin) by ELISA method
66
Total Activities
66
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity study of quinazoline derivatives leading to the discovery of potent EGFR-T790M inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 66 | 7.78 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3622664 | — | — | 1 | 9.05 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 9.00 |
| CHEMBL3622632 | — | — | 1 | 8.92 |
| CHEMBL3622645 | — | — | 1 | 8.92 |
| CHEMBL3622639 | — | — | 1 | 8.92 |
| CHEMBL3622617 | — | — | 1 | 8.74 |
| CHEMBL2110732 | DACOMITINIB ANHYDROUS | 4.0 | 1 | 8.74 |
| CHEMBL3622651 | — | — | 1 | 8.68 |
| CHEMBL3622665 | — | — | 1 | 8.68 |
| CHEMBL3622675 | — | — | 1 | 8.62 |
| CHEMBL3622672 | — | — | 1 | 8.57 |
| CHEMBL3622640 | — | — | 1 | 8.52 |
| CHEMBL3622674 | — | — | 1 | 8.48 |
| CHEMBL3622678 | — | — | 1 | 8.38 |
| CHEMBL3622671 | — | — | 1 | 8.28 |
| CHEMBL3622650 | — | — | 1 | 8.28 |
| CHEMBL3622637 | — | — | 1 | 8.27 |
| CHEMBL3622655 | — | — | 1 | 8.26 |
| CHEMBL3622676 | — | — | 1 | 8.25 |
| CHEMBL3622629 | — | — | 1 | 8.24 |
| CHEMBL3622648 | — | — | 1 | 8.22 |
| CHEMBL3622673 | — | — | 1 | 8.21 |
| CHEMBL3622666 | — | — | 1 | 8.19 |
| CHEMBL3622679 | — | — | 1 | 8.19 |
| CHEMBL3622668 | — | — | 1 | 8.16 |
| CHEMBL3622670 | — | — | 1 | 8.15 |
| CHEMBL3622677 | — | — | 1 | 8.10 |
| CHEMBL3622643 | — | — | 1 | 8.09 |
| CHEMBL3622649 | — | — | 1 | 8.09 |
| CHEMBL3622644 | — | — | 1 | 8.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3622664 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3622645 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3622639 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3622632 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3622617 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL2110732 | DACOMITINIB ANHYDROUS | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL3622651 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL3622665 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL3622675 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL3622672 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3622640 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3622674 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL3622678 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL3622650 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL3622671 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL3622637 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL3622655 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL3622676 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL3622629 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL3622648 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3622673 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL3622666 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL3622679 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL3622668 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL3622670 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3622677 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL3622643 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL3622649 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL3622644 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3622654 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL3622667 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL3622638 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3622653 | — | IC50 | = | 26.9 | nM | 7.57 |
| CHEMBL3622625 | — | IC50 | = | 32.2 | nM | 7.49 |
| CHEMBL3622622 | — | IC50 | = | 72.2 | nM | 7.14 |
| CHEMBL3622636 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL3622624 | — | IC50 | = | 100.1 | nM | 7.00 |
| CHEMBL3621220 | — | IC50 | = | 102.2 | nM | 6.99 |
| CHEMBL3622634 | — | IC50 | = | 102.3 | nM | 6.99 |
| CHEMBL3622626 | — | IC50 | = | 104.7 | nM | 6.98 |
| CHEMBL3622658 | — | IC50 | = | 109.4 | nM | 6.96 |
| CHEMBL3622619 | — | IC50 | = | 115.1 | nM | 6.94 |
| CHEMBL3622630 | — | IC50 | = | 121.1 | nM | 6.92 |
| CHEMBL3622623 | — | IC50 | = | 134.9 | nM | 6.87 |
| CHEMBL3622642 | — | IC50 | = | 133.9 | nM | 6.87 |
| CHEMBL3622669 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL3622647 | — | IC50 | = | 147.4 | nM | 6.83 |
| CHEMBL3622628 | — | IC50 | = | 167.3 | nM | 6.78 |
| CHEMBL3622620 | — | IC50 | = | 195.8 | nM | 6.71 |