Assay Detail
Functional
CHEMBL3625191
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against rat C6 cells assessed as inhibition of cell proliferation after 24 hrs by MTT assay
21
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | C6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of mitochondria-targeting berberine derivatives as the inhibitors of proliferation, invasion and migration against rat C6 and human U87 glioma cells
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.49 | 5.95 |
| Inhibition | 10 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3621412 | — | — | 2 | 5.95 |
| CHEMBL2313430 | — | — | 2 | 5.91 |
| CHEMBL3621410 | — | — | 2 | 5.78 |
| CHEMBL3621411 | — | — | 2 | 5.78 |
| CHEMBL3621409 | — | — | 2 | 5.62 |
| CHEMBL3621416 | — | — | 2 | 5.53 |
| CHEMBL3621414 | — | — | 2 | 5.35 |
| CHEMBL3621415 | — | — | 2 | 5.21 |
| CHEMBL3621413 | — | — | 2 | 4.94 |
| CHEMBL3621408 | — | — | 2 | 4.84 |
| CHEMBL12089 | BERBERINE CHLORIDE | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3621412 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL2313430 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL3621410 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL3621411 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL3621409 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL3621416 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL3621414 | — | IC50 | = | 4450.0 | nM | 5.35 |
| CHEMBL3621415 | — | IC50 | = | 6120.0 | nM | 5.21 |
| CHEMBL3621413 | — | IC50 | = | 11480.0 | nM | 4.94 |
| CHEMBL3621408 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL3621409 | — | Inhibition | - | % | - | |
| CHEMBL3621410 | — | Inhibition | - | % | - | |
| CHEMBL3621411 | — | Inhibition | - | % | - | |
| CHEMBL3621412 | — | Inhibition | - | % | - | |
| CHEMBL3621413 | — | Inhibition | - | % | - | |
| CHEMBL3621414 | — | Inhibition | - | % | - | |
| CHEMBL3621415 | — | Inhibition | - | % | - | |
| CHEMBL2313430 | — | Inhibition | - | % | - | |
| CHEMBL3621416 | — | Inhibition | - | % | - | |
| CHEMBL3621408 | — | Inhibition | - | % | - | |
| CHEMBL12089 | BERBERINE CHLORIDE | IC50 | > | 20000.0 | nM | - |