Assay Detail
Functional
CHEMBL3625192
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human U87 cells assessed as inhibition of cell proliferation after 24 hrs by MTT assay
21
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of mitochondria-targeting berberine derivatives as the inhibitors of proliferation, invasion and migration against rat C6 and human U87 glioma cells
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.22 | 5.51 |
| Inhibition | 10 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3621411 | — | — | 2 | 5.51 |
| CHEMBL3621410 | — | — | 2 | 5.49 |
| CHEMBL3621412 | — | — | 2 | 5.44 |
| CHEMBL2313430 | — | — | 2 | 5.34 |
| CHEMBL3621416 | — | — | 2 | 5.24 |
| CHEMBL3621409 | — | — | 2 | 5.24 |
| CHEMBL3621415 | — | — | 2 | 4.82 |
| CHEMBL3621414 | — | — | 2 | 4.65 |
| CHEMBL12089 | BERBERINE CHLORIDE | 1.0 | 1 | - |
| CHEMBL3621413 | — | — | 2 | - |
| CHEMBL3621408 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3621411 | — | IC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL3621410 | — | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL3621412 | — | IC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL2313430 | — | IC50 | = | 4550.0 | nM | 5.34 |
| CHEMBL3621416 | — | IC50 | = | 5730.0 | nM | 5.24 |
| CHEMBL3621409 | — | IC50 | = | 5750.0 | nM | 5.24 |
| CHEMBL3621415 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL3621414 | — | IC50 | = | 22490.0 | nM | 4.65 |
| CHEMBL3621415 | — | Inhibition | - | % | - | |
| CHEMBL2313430 | — | Inhibition | - | % | - | |
| CHEMBL3621416 | — | Inhibition | - | % | - | |
| CHEMBL12089 | BERBERINE CHLORIDE | IC50 | > | 20000.0 | nM | - |
| CHEMBL3621414 | — | Inhibition | - | % | - | |
| CHEMBL3621413 | — | Inhibition | - | % | - | |
| CHEMBL3621412 | — | Inhibition | - | % | - | |
| CHEMBL3621411 | — | Inhibition | - | % | - | |
| CHEMBL3621410 | — | Inhibition | - | % | - | |
| CHEMBL3621409 | — | Inhibition | - | % | - | |
| CHEMBL3621408 | — | Inhibition | - | % | - | |
| CHEMBL3621408 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3621413 | — | IC50 | > | 20000.0 | nM | - |