Assay Detail
Binding
CHEMBL3625239
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | 1321-N1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Characterization in Vitro and in Vivo of (l)-(Trimethylsilyl)alanine Containing Neurotensin Analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.53 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3622802 | — | — | 1 | 9.59 |
| CHEMBL415788 | — | — | 1 | 8.12 |
| CHEMBL3622806 | — | — | 1 | 7.67 |
| CHEMBL3622803 | — | — | 1 | 7.54 |
| CHEMBL3622805 | — | — | 1 | 7.53 |
| CHEMBL3622801 | — | — | 1 | 6.39 |
| CHEMBL3622804 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3622802 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL415788 | — | IC50 | = | 7.52 | nM | 8.12 |
| CHEMBL3622806 | — | IC50 | = | 21.2 | nM | 7.67 |
| CHEMBL3622803 | — | IC50 | = | 28.9 | nM | 7.54 |
| CHEMBL3622805 | — | IC50 | = | 29.7 | nM | 7.53 |
| CHEMBL3622801 | — | IC50 | = | 405.0 | nM | 6.39 |
| CHEMBL3622804 | — | IC50 | = | 1425.0 | nM | 5.85 |