Assay Detail
Binding
CHEMBL3625625
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Transactivation of VDR in human Caco2 cells after 24 hrs by luciferase reporter gene assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Caco-2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chemical Synthesis and Biological Activities of 20S,24S/R-Dihydroxyvitamin D3 Epimers and Their 1α-Hydroxyl Derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.88 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333950 | MAXACALCITOL | 3.0 | 1 | 7.39 |
| CHEMBL3623498 | — | — | 1 | 7.17 |
| CHEMBL3623500 | — | — | 1 | 6.68 |
| CHEMBL846 | CALCITRIOL | 4.0 | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333950 | MAXACALCITOL | EC50 | = | 40.8 | nM | 7.39 |
| CHEMBL3623498 | — | EC50 | = | 66.9 | nM | 7.17 |
| CHEMBL3623500 | — | EC50 | = | 207.9 | nM | 6.68 |
| CHEMBL846 | CALCITRIOL | EC50 | = | 515.2 | nM | 6.29 |