Assay Detail
Functional
CHEMBL3625635
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Vasodilatory activity in Wistar rat endothelium-denuded thoracic aorta assessed as reduction in phenylephrine-induced contraction
5
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
NO-Donor Dihydroartemisinin Derivatives as Multitarget Agents for the Treatment of Cerebral Malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.08 | 8.44 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3623714 | — | — | 1 | 8.44 |
| CHEMBL3623712 | — | — | 1 | 7.64 |
| CHEMBL3623713 | — | — | 1 | 6.39 |
| CHEMBL3623711 | — | — | 2 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3623714 | — | EC50 | = | 3.6 | nM | 8.44 |
| CHEMBL3623712 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3623713 | — | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL3623711 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3623711 | — | Activity | - | — | - |