Assay Detail

CHEMBL3625656

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Functional

Antiproliferative activity against mouse BAF3 cells expressing JAK2 V617F mutant incubated for 72 hrs by [3H] thymidine incorporation assay

ChEMBL ↗

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Target

BaF3 (CHEMBL614524) ↗

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Primary target BaF3

CHEMBL614524

Anchored from Assay target.

Protein identity BaF3

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Mus musculus
Cell Type	BaF3
Confidence	1 — Organism
Curated By	Autocuration

Target

BaF3 (CHEMBL614524) ↗

Type	CELL-LINE
Organism	Mus musculus

Publication

Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms.

Wan H, Schroeder GM, Hart AC, Inghrim J, Grebinski J, Tokarski JS, Lorenzi MV, You D, Mcdevitt T, Penhallow B, Vuppugalla R, Zhang Y, Gu X, Iyer R, Lombardo LJ, Trainor GL, Ruepp S, Lippy J, Blat Y, Sack JS, Khan JA, Stefanski K, Sleczka B, Mathur A, Sun JH, Wong MK, Wu DR, Li P, Gupta A, Arunachalam PN, Pragalathan B, Narayanan S, K C N, Kuppusamy P, Purandare AV.
ACS Med Chem Lett (2015) 6 : 850 -855
PubMed 26288683 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.16	7.16

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3545215	BMS-911543	2.0	1	7.16

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3545215	BMS-911543	IC50	=	70.0	nM	7.16