Assay Detail
Functional
CHEMBL3625680
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of nitric oxide production in LPS-stimulated mouse RAW264.7 cells preincubated for 15 mins followed by LPS challenge measured after 20 hrs by Griess assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Determination of the absolute configuration of chaetoviridins and other bioactive azaphilones from the endophytic fungus Chaetomium globosum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.44 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1797233 | CHAETOMUGILIN I | — | 1 | 6.52 |
| CHEMBL1797232 | — | — | 1 | 6.10 |
| CHEMBL3621758 | — | — | 1 | 5.72 |
| CHEMBL3621756 | — | — | 1 | 5.38 |
| CHEMBL3621757 | — | — | 1 | 5.24 |
| CHEMBL256147 | TILARGININE | 3.0 | 1 | 4.60 |
| CHEMBL494745 | CHAETOMUGILIN D | — | 1 | 4.55 |
| CHEMBL3621754 | — | — | 1 | - |
| CHEMBL3621755 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1797233 | CHAETOMUGILIN I | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1797232 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3621758 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3621756 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL3621757 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL256147 | TILARGININE | IC50 | = | 25100.0 | nM | 4.60 |
| CHEMBL494745 | CHAETOMUGILIN D | IC50 | = | 28100.0 | nM | 4.55 |
| CHEMBL3621754 | — | IC50 | - | — | - | |
| CHEMBL3621755 | — | IC50 | - | — | - |