Assay Detail
Binding
CHEMBL3625891
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JAK3 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Benzimidazole Derivatives as Potent JAK1-Selective Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.95 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3137308 | PEFICITINIB | 4.0 | 1 | 9.15 |
| CHEMBL3039513 | DECERNOTINIB | 2.0 | 1 | 8.60 |
| CHEMBL3301607 | FILGOTINIB | 4.0 | 1 | 6.09 |
| CHEMBL2105759 | BARICITINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3137308 | PEFICITINIB | IC50 | = | 0.71 | nM | 9.15 |
| CHEMBL3039513 | DECERNOTINIB | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL3301607 | FILGOTINIB | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL2105759 | BARICITINIB | IC50 | > | 400.0 | nM | - |