Assay Detail
Binding
CHEMBL3626166
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as reduction in Wnt ligand-driven LEF/TCF-dependent transcriptional activity
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Wnt3A |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein-serine O-palmitoleoyltransferase porcupine (CHEMBL1255163) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Exploration of the linkage elements of porcupine antagonists led to potent Wnt signaling pathway inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 8.25 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3623895 | — | — | 1 | 9.96 |
| CHEMBL3623894 | — | — | 1 | 9.72 |
| CHEMBL3623875 | — | — | 1 | 9.64 |
| CHEMBL3623893 | — | — | 1 | 9.28 |
| CHEMBL3623896 | — | — | 1 | 9.24 |
| CHEMBL3623892 | — | — | 1 | 9.17 |
| CHEMBL3623891 | — | — | 1 | 9.02 |
| CHEMBL3623874 | — | — | 1 | 8.66 |
| CHEMBL3623887 | — | — | 1 | 8.57 |
| CHEMBL3623873 | — | — | 1 | 8.30 |
| CHEMBL3623889 | — | — | 1 | 7.62 |
| CHEMBL3623879 | — | — | 1 | 7.52 |
| CHEMBL3623878 | — | — | 1 | 7.40 |
| CHEMBL3623877 | — | — | 1 | 6.79 |
| CHEMBL3623876 | — | — | 1 | 6.73 |
| CHEMBL3623890 | — | — | 1 | 6.32 |
| CHEMBL3623888 | — | — | 1 | 6.31 |
| CHEMBL3623886 | — | — | 1 | - |
| CHEMBL3623885 | — | — | 1 | - |
| CHEMBL3623884 | — | — | 1 | - |
| CHEMBL3623883 | — | — | 1 | - |
| CHEMBL3623882 | — | — | 1 | - |
| CHEMBL3623881 | — | — | 1 | - |
| CHEMBL3623880 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3623895 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL3623894 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL3623875 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL3623893 | — | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL3623896 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL3623892 | — | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL3623891 | — | IC50 | = | 0.96 | nM | 9.02 |
| CHEMBL3623874 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3623887 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3623873 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3623889 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3623879 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3623878 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3623877 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL3623876 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL3623890 | — | IC50 | = | 483.0 | nM | 6.32 |
| CHEMBL3623888 | — | IC50 | = | 485.0 | nM | 6.31 |
| CHEMBL3623886 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3623885 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3623884 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3623883 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3623882 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3623881 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3623880 | — | IC50 | > | 1000.0 | nM | - |