Assay Detail
Binding
CHEMBL3626252
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Inhibition of bovine liver beta-glucosidase using 10 mM p-nitrophenyl-alpha-D-glucopyranoside as substrate
16
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Quaternary Indolizidine and Indolizidone Iminosugars as Potential Immunostimulating and Glycosidase Inhibitory Agents: Synthesis, Conformational Analysis, Biological Activity, and Molecular Docking Study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 4.48 | 4.96 |
| IC50 | 8 | 4.47 | 4.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3621532 | — | — | 2 | 4.96 |
| CHEMBL3621533 | — | — | 2 | 4.72 |
| CHEMBL3621530 | — | — | 2 | 4.62 |
| CHEMBL1561 | MIGLITOL | 4.0 | 2 | 4.50 |
| CHEMBL3621209 | — | — | 2 | 4.07 |
| CHEMBL3621528 | — | — | 2 | 4.02 |
| CHEMBL3621531 | — | — | 2 | - |
| CHEMBL3621529 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3621532 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL3621533 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL3621532 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL3621530 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL1561 | MIGLITOL | Ki | = | 32000.0 | nM | 4.50 |
| CHEMBL3621533 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL3621530 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL3621209 | — | Ki | = | 86000.0 | nM | 4.07 |
| CHEMBL3621528 | — | Ki | = | 95000.0 | nM | 4.02 |
| CHEMBL1561 | MIGLITOL | IC50 | = | 342000.0 | nM | - |
| CHEMBL3621531 | — | Ki | = | 113000.0 | nM | - |
| CHEMBL3621531 | — | IC50 | = | 342000.0 | nM | - |
| CHEMBL3621529 | — | Ki | = | 102000.0 | nM | - |
| CHEMBL3621529 | — | IC50 | = | 202000.0 | nM | - |
| CHEMBL3621528 | — | IC50 | = | 116000.0 | nM | - |
| CHEMBL3621209 | — | IC50 | = | 156000.0 | nM | - |