Assay Detail
Functional
CHEMBL3626326
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 RF infected in CEM-SS cells assessed as inhibition of virus-induced cytopathic effect by MTS assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Novel anti-HIV-1 NNRTIs based on a pyrazolo[4,3-d]isoxazole backbone scaffold: design, synthesis and insights into the molecular basis of action
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 9.35 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3621609 | — | — | 1 | 9.60 |
| CHEMBL3621605 | — | — | 1 | 9.60 |
| CHEMBL3621607 | — | — | 1 | 9.47 |
| CHEMBL3621608 | — | — | 1 | 9.46 |
| CHEMBL3621606 | — | — | 1 | 9.44 |
| CHEMBL3621613 | — | — | 1 | 9.37 |
| CHEMBL3621612 | — | — | 1 | 9.36 |
| CHEMBL3621611 | — | — | 1 | 9.34 |
| CHEMBL3621610 | — | — | 1 | 9.33 |
| CHEMBL3621604 | — | — | 1 | 9.27 |
| CHEMBL3621614 | — | — | 1 | 9.17 |
| CHEMBL3621603 | — | — | 1 | 9.11 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 9.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3621609 | — | EC50 | = | 0.25 | nM | 9.60 |
| CHEMBL3621605 | — | EC50 | = | 0.25 | nM | 9.60 |
| CHEMBL3621607 | — | EC50 | = | 0.34 | nM | 9.47 |
| CHEMBL3621608 | — | EC50 | = | 0.35 | nM | 9.46 |
| CHEMBL3621606 | — | EC50 | = | 0.36 | nM | 9.44 |
| CHEMBL3621613 | — | EC50 | = | 0.43 | nM | 9.37 |
| CHEMBL3621612 | — | EC50 | = | 0.44 | nM | 9.36 |
| CHEMBL3621611 | — | EC50 | = | 0.46 | nM | 9.34 |
| CHEMBL3621610 | — | EC50 | = | 0.47 | nM | 9.33 |
| CHEMBL3621604 | — | EC50 | = | 0.54 | nM | 9.27 |
| CHEMBL3621614 | — | EC50 | = | 0.67 | nM | 9.17 |
| CHEMBL3621603 | — | EC50 | = | 0.78 | nM | 9.11 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 0.92 | nM | 9.04 |