Assay Detail
Functional
CHEMBL3626396
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Growth inhibition of human NB4 cells after 72 hrs
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NB-4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Investigation on the ZBG-functionality of phenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.62 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.16 |
| CHEMBL556532 | — | — | 1 | 6.05 |
| CHEMBL3621537 | — | — | 1 | 5.71 |
| CHEMBL3621535 | — | — | 1 | 5.15 |
| CHEMBL3621536 | — | — | 1 | 5.01 |
| CHEMBL3621534 | — | — | 1 | - |
| CHEMBL3621538 | — | — | 1 | - |
| CHEMBL3621539 | — | — | 1 | - |
| CHEMBL3621540 | — | — | 1 | - |
| CHEMBL3621541 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL556532 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3621537 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL3621535 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL3621536 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL3621534 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3621538 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3621539 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3621540 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3621541 | — | IC50 | > | 20000.0 | nM | - |