Assay Detail
Binding
CHEMBL3626446
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Inhibition of recombinant human AChE after 10 mins by Ellman assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.63 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3623551 | — | — | 1 | 8.42 |
| CHEMBL3623552 | — | — | 1 | 8.28 |
| CHEMBL3623554 | — | — | 1 | 8.22 |
| CHEMBL3623549 | — | — | 1 | 8.19 |
| CHEMBL3623550 | — | — | 1 | 8.15 |
| CHEMBL89354 | — | — | 1 | 7.84 |
| CHEMBL3623558 | — | — | 1 | 7.54 |
| CHEMBL3623548 | — | — | 1 | 7.11 |
| CHEMBL3623556 | — | — | 1 | 6.96 |
| CHEMBL3623557 | — | — | 1 | 6.83 |
| CHEMBL3623559 | — | — | 1 | 6.68 |
| CHEMBL3137700 | — | — | 1 | 6.54 |
| CHEMBL3623561 | — | — | 1 | 6.24 |
| CHEMBL3623553 | — | — | 1 | 6.23 |
| CHEMBL3623555 | — | — | 1 | 6.10 |
| CHEMBL167911 | DICHLORVOS | 2.0 | 1 | 5.64 |
| CHEMBL446060 | PROPOXUR | -1.0 | 1 | 5.64 |
| CHEMBL3623566 | — | — | 1 | 5.60 |
| CHEMBL3623565 | — | — | 1 | 5.28 |
| CHEMBL3623560 | — | — | 1 | 5.01 |
| CHEMBL3623563 | — | — | 1 | 4.77 |
| CHEMBL3623564 | — | — | 1 | 4.62 |
| CHEMBL3623562 | — | — | 1 | - |
| CHEMBL3623567 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3623551 | — | IC50 | = | 3.77 | nM | 8.42 |
| CHEMBL3623552 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL3623554 | — | IC50 | = | 6.05 | nM | 8.22 |
| CHEMBL3623549 | — | IC50 | = | 6.47 | nM | 8.19 |
| CHEMBL3623550 | — | IC50 | = | 7.15 | nM | 8.15 |
| CHEMBL89354 | — | IC50 | = | 14.6 | nM | 7.84 |
| CHEMBL3623558 | — | IC50 | = | 28.8 | nM | 7.54 |
| CHEMBL3623548 | — | IC50 | = | 77.5 | nM | 7.11 |
| CHEMBL3623556 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3623557 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL3623559 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL3137700 | — | IC50 | = | 285.0 | nM | 6.54 |
| CHEMBL3623561 | — | IC50 | = | 578.0 | nM | 6.24 |
| CHEMBL3623553 | — | IC50 | = | 591.0 | nM | 6.23 |
| CHEMBL3623555 | — | IC50 | = | 802.0 | nM | 6.10 |
| CHEMBL167911 | DICHLORVOS | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL446060 | PROPOXUR | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3623566 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3623565 | — | IC50 | = | 5290.0 | nM | 5.28 |
| CHEMBL3623560 | — | IC50 | = | 9780.0 | nM | 5.01 |
| CHEMBL3623563 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL3623564 | — | IC50 | = | 24200.0 | nM | 4.62 |
| CHEMBL3623562 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3623567 | — | IC50 | > | 10000.0 | nM | - |