Assay Detail
Functional
CHEMBL3626465
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Cytotoxicity against human HL60 cells assessed as growth inhibition incubated for 72 hrs by CCK8 assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, cytotoxicity and inhibition of NO production of ivangustin enantiomer analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.45 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.70 |
| CHEMBL3622080 | — | — | 1 | 5.99 |
| CHEMBL3622083 | — | — | 1 | 5.42 |
| CHEMBL3622082 | — | — | 1 | 5.30 |
| CHEMBL3621396 | — | — | 1 | 5.14 |
| CHEMBL3622079 | — | — | 1 | 5.03 |
| CHEMBL3622084 | — | — | 1 | 4.90 |
| CHEMBL3622078 | — | — | 1 | 4.83 |
| CHEMBL3622081 | — | — | 1 | 4.78 |
| CHEMBL3622085 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3622080 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL3622083 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL3622082 | — | IC50 | = | 5060.0 | nM | 5.30 |
| CHEMBL3621396 | — | IC50 | = | 7310.0 | nM | 5.14 |
| CHEMBL3622079 | — | IC50 | = | 9370.0 | nM | 5.03 |
| CHEMBL3622084 | — | IC50 | = | 12590.0 | nM | 4.90 |
| CHEMBL3622078 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL3622081 | — | IC50 | = | 16450.0 | nM | 4.78 |
| CHEMBL3622085 | — | IC50 | > | 50000.0 | nM | - |