Assay Detail
Functional
CHEMBL3626470
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Anti-inflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of nitric oxide production incubated for 20 mins before LPS induction by Griess method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, cytotoxicity and inhibition of NO production of ivangustin enantiomer analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.25 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3622082 | — | — | 1 | 5.46 |
| CHEMBL3622083 | — | — | 1 | 5.37 |
| CHEMBL3621396 | — | — | 1 | 5.33 |
| CHEMBL3622080 | — | — | 1 | 5.33 |
| CHEMBL3622085 | — | — | 1 | 5.29 |
| CHEMBL3622084 | — | — | 1 | 5.24 |
| CHEMBL3622078 | — | — | 1 | 5.21 |
| CHEMBL3622079 | — | — | 1 | 5.17 |
| CHEMBL3622081 | — | — | 1 | 5.16 |
| CHEMBL225304 | PIMAGEDINE | 2.0 | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3622082 | — | IC50 | = | 3440.0 | nM | 5.46 |
| CHEMBL3622083 | — | IC50 | = | 4260.0 | nM | 5.37 |
| CHEMBL3621396 | — | IC50 | = | 4630.0 | nM | 5.33 |
| CHEMBL3622080 | — | IC50 | = | 4720.0 | nM | 5.33 |
| CHEMBL3622085 | — | IC50 | = | 5170.0 | nM | 5.29 |
| CHEMBL3622084 | — | IC50 | = | 5820.0 | nM | 5.24 |
| CHEMBL3622078 | — | IC50 | = | 6120.0 | nM | 5.21 |
| CHEMBL3622079 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL3622081 | — | IC50 | = | 6990.0 | nM | 5.16 |
| CHEMBL225304 | PIMAGEDINE | IC50 | = | 11910.0 | nM | 4.92 |