Assay Detail
Binding
CHEMBL3626514
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Inhibition of BChE from human plasma
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Macrocyclic derivatives of 6-methyluracil as ligands of the peripheral anionic site of acetylcholinesterase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.28 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL812 | PYRIDOSTIGMINE BROMIDE | 4.0 | 1 | 6.00 |
| CHEMBL3621333 | — | — | 1 | 5.92 |
| CHEMBL3621332 | — | — | 1 | 5.04 |
| CHEMBL3621334 | — | — | 1 | 5.00 |
| CHEMBL3621322 | — | — | 1 | 5.00 |
| CHEMBL3621335 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL812 | PYRIDOSTIGMINE BROMIDE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3621333 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3621332 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL3621334 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3621322 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3621335 | — | IC50 | = | 20000.0 | nM | 4.70 |