Assay Detail

CHEMBL3626552

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Binding

Displacement of [3H]histamine from rat recombinant histamine H4 receptor

ChEMBL ↗

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Target

Histamine H4 receptor (CHEMBL4468) ↗

Open DB target context

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Primary target Histamine H4 receptor

CHEMBL4468

Anchored from Assay target.

Protein identity Histamine H4 receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Rattus norvegicus
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Histamine H4 receptor (CHEMBL4468) ↗

Type	SINGLE PROTEIN
Organism	Rattus norvegicus

Publication

Functional Profiling of 2-Aminopyrimidine Histamine H4 Receptor Modulators.

Tichenor MS, Thurmond RL, Venable JD, Savall BM.
J Med Chem (2015) 58 : 7119 -7127
PubMed 25993395 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	6.73	6.73

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3236549	JNJ-39758979	2.0	1	6.73

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3236549	JNJ-39758979	Ki	=	188.0	nM	6.73