Assay Detail
Functional
CHEMBL3626663
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Antiparasitic activity against bloodstream form of Trypanosoma brucei brucei 427 infected in macrophages differentiated from human THP1 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
17
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.93 | 8.80 |
| GI | 6 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.80 |
| CHEMBL3622702 | — | — | 2 | 4.31 |
| CHEMBL297258 | — | — | 2 | 4.24 |
| CHEMBL3622700 | — | — | 2 | 4.13 |
| CHEMBL3622699 | — | — | 2 | 4.05 |
| CHEMBL3622701 | — | — | 2 | 4.04 |
| CHEMBL3622703 | — | — | 1 | - |
| CHEMBL3622704 | — | — | 1 | - |
| CHEMBL3622705 | — | — | 1 | - |
| CHEMBL3622706 | — | — | 1 | - |
| CHEMBL3622707 | — | — | 1 | - |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3622702 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL297258 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL3622700 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL3622699 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL3622701 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL3622703 | — | IC50 | - | — | - | |
| CHEMBL3622704 | — | IC50 | - | — | - | |
| CHEMBL3622705 | — | IC50 | - | — | - | |
| CHEMBL3622706 | — | IC50 | - | — | - | |
| CHEMBL3622707 | — | IC50 | - | — | - | |
| CHEMBL265502 | SURAMIN | GI | - | — | - | |
| CHEMBL3622699 | — | GI | - | — | - | |
| CHEMBL3622700 | — | GI | - | — | - | |
| CHEMBL3622701 | — | GI | - | — | - | |
| CHEMBL3622702 | — | GI | - | — | - | |
| CHEMBL297258 | — | GI | - | — | - |