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Assay Detail

CHEMBL3626669

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]diprenorphine from FLAG-tagged mouse delta opioid receptor expressed in CHO cell membranes
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Delta-type opioid receptor (CHEMBL3222)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Synthesis and biological evaluation of 2-alkyl-2-methoxymethyl-salvinorin ethers as selective κ-opioid receptor agonists.
Lee DY, Deng G, Ma Z, Xu W, Yang L, Liu J, Dai R, Liu-Chen LY.
Bioorg Med Chem Lett (2015) 25 : 4689 -4692
PubMed 26330078 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 8.54 8.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL140050 ETORPHINE 2.0 1 8.54
CHEMBL3622715 1 -
CHEMBL3622714 1 -
CHEMBL3622708 1 -
CHEMBL3622709 1 -
CHEMBL3622710 1 -
CHEMBL3622711 1 -
CHEMBL3622712 1 -
CHEMBL3622713 1 -
CHEMBL424698 SALVINORIN B 1 -
CHEMBL445332 SALVINORIN A 1.0 1 -
CHEMBL3622718 1 -
CHEMBL3622717 1 -
CHEMBL3622716 1 -
CHEMBL3621221 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL140050 ETORPHINE Ki = 2.9 nM 8.54
CHEMBL3622715 Ki > 1000.0 nM -
CHEMBL3622714 Ki > 1000.0 nM -
CHEMBL3622708 Ki > 1000.0 nM -
CHEMBL3622709 Ki > 1000.0 nM -
CHEMBL3622710 Ki > 1000.0 nM -
CHEMBL3622711 Ki > 1000.0 nM -
CHEMBL3622712 Ki > 1000.0 nM -
CHEMBL3622713 Ki > 1000.0 nM -
CHEMBL424698 SALVINORIN B Ki > 1000.0 nM -
CHEMBL445332 SALVINORIN A Ki > 1000.0 nM -
CHEMBL3622718 Ki > 1000.0 nM -
CHEMBL3622717 Ki > 1000.0 nM -
CHEMBL3622716 Ki > 1000.0 nM -
CHEMBL3621221 Ki > 1000.0 nM -