Assay Detail
Binding
CHEMBL3626954
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant HDAC3/NCoR2 using Ac-Leu-Gly-Lys (Ac)-AMC substrate incubated for 45 mins by fluorescence assay based continuous assay protocol
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) (CHEMBL2111363) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
An azumamide C analogue without the zinc-binding functionality
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.47 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 8.27 |
| CHEMBL257972 | AZUMAMIDE C | — | 1 | 8.02 |
| CHEMBL3621348 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | Ki | = | 5.42 | nM | 8.27 |
| CHEMBL257972 | AZUMAMIDE C | Ki | = | 9.67 | nM | 8.02 |
| CHEMBL3621348 | — | Ki | = | 780.0 | nM | 6.11 |