Assay Detail
Functional
CHEMBL3627290
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Cytotoxicity against human SKHEP1 cells assessed as growth inhibition after 72 hrs by SRB assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-HEP1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.40 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3623795 | — | — | 1 | 9.47 |
| CHEMBL198075 | CRYPTOPLEURINE | — | 1 | 9.08 |
| CHEMBL3623797 | — | — | 1 | 8.82 |
| CHEMBL3623801 | — | — | 1 | 8.79 |
| CHEMBL3623802 | — | — | 1 | 8.60 |
| CHEMBL3623794 | — | — | 1 | 8.35 |
| CHEMBL228286 | (-)-ANTOFINE | — | 1 | 8.20 |
| CHEMBL3623799 | — | — | 1 | 7.31 |
| CHEMBL3623800 | — | — | 1 | 7.00 |
| CHEMBL3623796 | — | — | 1 | - |
| CHEMBL3623798 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3623795 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL198075 | CRYPTOPLEURINE | IC50 | = | 0.83 | nM | 9.08 |
| CHEMBL3623797 | — | IC50 | = | 1.52 | nM | 8.82 |
| CHEMBL3623801 | — | IC50 | = | 1.64 | nM | 8.79 |
| CHEMBL3623802 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL3623794 | — | IC50 | = | 4.44 | nM | 8.35 |
| CHEMBL228286 | (-)-ANTOFINE | IC50 | = | 6.32 | nM | 8.20 |
| CHEMBL3623799 | — | IC50 | = | 49.23 | nM | 7.31 |
| CHEMBL3623800 | — | IC50 | = | 99.48 | nM | 7.00 |
| CHEMBL3623796 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL3623798 | — | IC50 | > | 100.0 | nM | - |