Assay Detail
Binding
CHEMBL3627445
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Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation measured after 15 mins by flow cytometric analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Ramos B |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Orally bioavailable Syk inhibitors with activity in a rat PK/PD model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.68 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3622204 | — | — | 1 | 7.05 |
| CHEMBL3416026 | — | — | 1 | 7.00 |
| CHEMBL3622698 | — | — | 1 | 6.97 |
| CHEMBL3622208 | — | — | 1 | 6.88 |
| CHEMBL3622206 | — | — | 1 | 6.79 |
| CHEMBL3622209 | — | — | 1 | 6.78 |
| CHEMBL2177736 | — | — | 1 | 6.75 |
| CHEMBL3622207 | — | — | 1 | 6.61 |
| CHEMBL3622203 | — | — | 1 | 6.55 |
| CHEMBL3622205 | — | — | 1 | 6.55 |
| CHEMBL3622697 | — | — | 1 | 6.48 |
| CHEMBL3622210 | — | — | 1 | 6.47 |
| CHEMBL30678 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3622204 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL3416026 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL3622698 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL3622208 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL3622206 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL3622209 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL2177736 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL3622207 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL3622203 | — | IC50 | = | 284.0 | nM | 6.55 |
| CHEMBL3622205 | — | IC50 | = | 284.0 | nM | 6.55 |
| CHEMBL3622697 | — | IC50 | = | 328.0 | nM | 6.48 |
| CHEMBL3622210 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL30678 | — | IC50 | = | 951.0 | nM | 6.02 |