Assay Detail
Functional
CHEMBL3630579
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Agonist activity at human beta2 adrenoceptor expressed in CHO cells assessed as stumulation of intracellular cAMP production
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Molecular hybridization yields triazole bronchodilators for the treatment of COPD.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.87 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1773267 | — | — | 1 | 8.62 |
| CHEMBL3629353 | — | — | 1 | 8.43 |
| CHEMBL3629356 | — | — | 1 | 7.89 |
| CHEMBL3629359 | — | — | 1 | 7.85 |
| CHEMBL3629358 | — | — | 1 | 7.68 |
| CHEMBL3629360 | — | — | 1 | 7.68 |
| CHEMBL3629357 | — | — | 1 | 6.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1773267 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL3629353 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL3629356 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3629359 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3629358 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3629360 | — | EC50 | = | 20.9 | nM | 7.68 |
| CHEMBL3629357 | — | EC50 | = | 116.0 | nM | 6.94 |