Assay Detail
Binding
CHEMBL3630581
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M3 receptor by dilution method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Molecular hybridization yields triazole bronchodilators for the treatment of COPD.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.83 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3629360 | — | — | 1 | 9.54 |
| CHEMBL1773267 | — | — | 1 | 9.51 |
| CHEMBL3629354 | — | — | 1 | 9.47 |
| CHEMBL3629353 | — | — | 1 | 9.14 |
| CHEMBL143228 | — | — | 1 | 8.96 |
| CHEMBL3629355 | — | — | 1 | 8.96 |
| CHEMBL3629356 | — | — | 1 | 8.43 |
| CHEMBL3629359 | — | — | 1 | 8.43 |
| CHEMBL3629358 | — | — | 1 | 8.11 |
| CHEMBL3629357 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3629360 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL1773267 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL3629354 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL3629353 | — | Ki | = | 0.73 | nM | 9.14 |
| CHEMBL143228 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL3629355 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL3629356 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL3629359 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL3629358 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL3629357 | — | Ki | = | 18.0 | nM | 7.75 |