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Assay Detail

CHEMBL3630976

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HIV1 3B infected in PBMC
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Discovery of novel N-aryl piperazine CXCR4 antagonists.
Zhao H, Prosser AR, Liotta DC, Wilson LJ.
Bioorg Med Chem Lett (2015) 25 : 4950 -4955
PubMed 25935642 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 7.34 7.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3091687 1 7.62
CHEMBL3627794 1 7.06

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3091687 IC50 = 24.0 nM 7.62
CHEMBL3627794 IC50 = 88.0 nM 7.06