Assay Detail
Binding
CHEMBL3631191
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New natural product carbonic anhydrase inhibitors incorporating phenol moieties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 7.66 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.60 |
| CHEMBL399121 | HESPERETIN | 0.5 | 1 | 8.48 |
| CHEMBL250450 | ISOQUERCETIN | 2.0 | 1 | 8.42 |
| CHEMBL2262641 | QUERCETIN-3-O-RHAMNOSIDE | — | 1 | 8.41 |
| CHEMBL8145 | DAIDZEIN | 2.0 | 1 | 8.38 |
| CHEMBL9352 | NARINGENIN | — | 1 | 8.37 |
| CHEMBL8996 | ERIODICTYOL | — | 1 | 8.37 |
| CHEMBL379064 | ISORHAMNETIN | — | 1 | 8.36 |
| CHEMBL266564 | TILIROSIDE | — | 1 | 8.34 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 8.33 |
| CHEMBL3628129 | — | — | 1 | 8.33 |
| CHEMBL309490 | GALANGIN | — | 1 | 7.61 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 7.60 |
| CHEMBL3628130 | — | — | 1 | 7.58 |
| CHEMBL541265 | SALVIANOLIC ACID B | — | 1 | 7.45 |
| CHEMBL457077 | SALVIANOLIC ACID A | 1.0 | 1 | 7.15 |
| CHEMBL117 | CHRYSIN | — | 1 | 6.77 |
| CHEMBL518243 | LITHOSPERMIC ACID | — | 1 | 6.57 |
| CHEMBL131921 | BIOCHANIN | — | 1 | 6.43 |
| CHEMBL233930 | ASTRAGALIN | — | 1 | 6.37 |
| CHEMBL486386 | PUERARIN | 2.0 | 1 | 6.34 |
| CHEMBL66 | (+)-TAXIFOLIN | — | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL399121 | HESPERETIN | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL250450 | ISOQUERCETIN | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL2262641 | QUERCETIN-3-O-RHAMNOSIDE | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL8145 | DAIDZEIN | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL9352 | NARINGENIN | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL8996 | ERIODICTYOL | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL379064 | ISORHAMNETIN | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL266564 | TILIROSIDE | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL151 | LUTEOLIN | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL3628129 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL309490 | GALANGIN | Ki | = | 24.5 | nM | 7.61 |
| CHEMBL150 | KAEMPFEROL | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL3628130 | — | Ki | = | 26.6 | nM | 7.58 |
| CHEMBL541265 | SALVIANOLIC ACID B | Ki | = | 35.5 | nM | 7.45 |
| CHEMBL457077 | SALVIANOLIC ACID A | Ki | = | 71.4 | nM | 7.15 |
| CHEMBL117 | CHRYSIN | Ki | = | 171.41 | nM | 6.77 |
| CHEMBL518243 | LITHOSPERMIC ACID | Ki | = | 268.3 | nM | 6.57 |
| CHEMBL131921 | BIOCHANIN | Ki | = | 371.5 | nM | 6.43 |
| CHEMBL233930 | ASTRAGALIN | Ki | = | 423.7 | nM | 6.37 |
| CHEMBL486386 | PUERARIN | Ki | = | 452.6 | nM | 6.34 |
| CHEMBL66 | (+)-TAXIFOLIN | Ki | = | 493.1 | nM | 6.31 |