Assay Detail

CHEMBL3631195

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Binding

Inhibition of human recombinant carbonic anhydrase 4

ChEMBL ↗

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Target

Carbonic anhydrase 4 (CHEMBL3729) ↗

Open DB target context

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Carbonic anhydrase 4 (CHEMBL3729) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Carbonic anhydrase 4

CHEMBL3729

Anchored from Assay target.

Protein identity Carbonic anhydrase 4

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Carbonic anhydrase 4 (CHEMBL3729) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

New natural product carbonic anhydrase inhibitors incorporating phenol moieties.

Karioti A, Ceruso M, Carta F, Bilia AR, Supuran CT.
Bioorg Med Chem (2015) 23 : 7219 -7225
PubMed 26498393 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	6.53	6.53

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL151	LUTEOLIN	2.0	1	6.53

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL151	LUTEOLIN	Ki	=	293.0	nM	6.53