Assay Detail
Binding
CHEMBL3631202
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Inhibition of human carbonic anhydrase 5B preincubated for 15 mins by stopped-flow CO2 hydration assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Carbonic anhydrase 5B, mitochondrial (CHEMBL3969) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibition of mammalian carbonic anhydrase isoforms I-XIV with a series of phenolic acid esters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.13 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3628211 | — | — | 1 | 6.21 |
| CHEMBL457076 | BENZYL FERULATE | — | 1 | 6.18 |
| CHEMBL481245 | — | — | 1 | 6.17 |
| CHEMBL3628131 | — | — | 1 | 6.13 |
| CHEMBL3628210 | — | — | 1 | 6.12 |
| CHEMBL1095574 | — | — | 1 | 6.10 |
| CHEMBL3628212 | — | — | 1 | 6.09 |
| CHEMBL3628132 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3628211 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL457076 | BENZYL FERULATE | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL481245 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL3628131 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL3628210 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL1095574 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL3628212 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL3628132 | — | Ki | = | 880.0 | nM | 6.06 |