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Assay Detail

CHEMBL3631207

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of mouse carbonic anhydrase 13 preincubated for 15 mins by stopped-flow CO2 hydration assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 13 (CHEMBL2186)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Inhibition of mammalian carbonic anhydrase isoforms I-XIV with a series of phenolic acid esters.
Maresca A, Akyuz G, Osman SM, AlOthman Z, Supuran CT.
Bioorg Med Chem (2015) 23 : 7181 -7188
PubMed 26498394 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 11 5.45 6.08

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3628131 1 6.08
CHEMBL3628132 1 6.05
CHEMBL3628210 1 6.04
CHEMBL457076 BENZYL FERULATE 1 6.03
CHEMBL481245 1 6.03
CHEMBL1095574 1 5.05
CHEMBL66879 COUMARIC ACID 1 5.00
CHEMBL145 CAFFEIC ACID 3.0 1 4.96
CHEMBL3628212 1 4.94
CHEMBL32749 FERULATE -1.0 1 4.91
CHEMBL3628211 1 4.86

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3628131 Ki = 840.0 nM 6.08
CHEMBL3628132 Ki = 900.0 nM 6.05
CHEMBL3628210 Ki = 910.0 nM 6.04
CHEMBL457076 BENZYL FERULATE Ki = 940.0 nM 6.03
CHEMBL481245 Ki = 930.0 nM 6.03
CHEMBL1095574 Ki = 8920.0 nM 5.05
CHEMBL66879 COUMARIC ACID Ki = 10100.0 nM 5.00
CHEMBL145 CAFFEIC ACID Ki = 10900.0 nM 4.96
CHEMBL3628212 Ki = 11600.0 nM 4.94
CHEMBL32749 FERULATE Ki = 12200.0 nM 4.91
CHEMBL3628211 Ki = 13900.0 nM 4.86