Assay Detail
Binding
CHEMBL3631861
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5-LO in mouse BMM cells assessed as formation of LTC4 after 30 mins by enzyme immunoassay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | BMM |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL5211) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
5-Lipoxygenase inhibitors suppress RANKL-induced osteoclast formation via NFATc1 expression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.80 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93 | ZILEUTON | 4.0 | 1 | 6.72 |
| CHEMBL3629175 | — | — | 1 | 5.76 |
| CHEMBL3629176 | — | — | 1 | 5.39 |
| CHEMBL3629177 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93 | ZILEUTON | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3629175 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL3629176 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3629177 | — | IC50 | = | 4900.0 | nM | 5.31 |