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Assay Detail

CHEMBL3631998

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of jack bean urease using urea as substrate assessed as ammonia production incubated for 15 mins by indophenol method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Canavalia ensiformis
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Urease (CHEMBL4161)
Type SINGLE PROTEIN
Organism Canavalia ensiformis

Publication

Synthesis of potent urease inhibitors based on disulfide scaffold and their molecular docking studies.
Taha M, Ismail NH, Imran S, Wadood A, Rahim F, Riaz M.
Bioorg Med Chem (2015) 23 : 7211 -7218
PubMed 26507431 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 5.41 6.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3629072 1 6.40
CHEMBL3629545 1 6.16
CHEMBL3629548 1 5.96
CHEMBL3629071 1 5.85
CHEMBL3629078 1 5.82
CHEMBL3629076 1 5.82
CHEMBL3629549 1 5.80
CHEMBL3629546 1 5.77
CHEMBL3629543 1 5.50
CHEMBL3629544 1 5.47
CHEMBL3629077 1 5.43
CHEMBL3629074 1 5.38
CHEMBL3629073 1 5.37
CHEMBL3629075 1 5.19
CHEMBL3629079 1 4.99
CHEMBL3629081 1 4.91
CHEMBL3629080 1 4.84
CHEMBL3629551 1 4.82
CHEMBL3629550 1 4.75
CHEMBL3629547 1 4.73
CHEMBL260876 THIOUREA 1 4.71

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3629072 IC50 = 400.0 nM 6.40
CHEMBL3629545 IC50 = 700.0 nM 6.16
CHEMBL3629548 IC50 = 1100.0 nM 5.96
CHEMBL3629071 IC50 = 1400.0 nM 5.85
CHEMBL3629078 IC50 = 1500.0 nM 5.82
CHEMBL3629076 IC50 = 1500.0 nM 5.82
CHEMBL3629549 IC50 = 1600.0 nM 5.80
CHEMBL3629546 IC50 = 1700.0 nM 5.77
CHEMBL3629543 IC50 = 3200.0 nM 5.50
CHEMBL3629544 IC50 = 3400.0 nM 5.47
CHEMBL3629077 IC50 = 3700.0 nM 5.43
CHEMBL3629074 IC50 = 4200.0 nM 5.38
CHEMBL3629073 IC50 = 4300.0 nM 5.37
CHEMBL3629075 IC50 = 6400.0 nM 5.19
CHEMBL3629079 IC50 = 10300.0 nM 4.99
CHEMBL3629081 IC50 = 12300.0 nM 4.91
CHEMBL3629080 IC50 = 14600.0 nM 4.84
CHEMBL3629551 IC50 = 15140.0 nM 4.82
CHEMBL3629550 IC50 = 17600.0 nM 4.75
CHEMBL3629547 IC50 = 18600.0 nM 4.73
CHEMBL260876 THIOUREA IC50 = 19460.0 nM 4.71