Assay Detail
Binding
CHEMBL3635481
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Inhibition of AChE (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A computational view on the significance of E-ring in binding of (+)-arisugacin A to acetylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.18 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL395280 | HUPERZINE A | 2.0 | 1 | 8.30 |
| CHEMBL636 | RIVASTIGMINE | 4.0 | 1 | 7.27 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.70 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL395280 | HUPERZINE A | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL636 | RIVASTIGMINE | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL95 | TACRINE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 350.0 | nM | 6.46 |