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Assay Detail

CHEMBL3635482

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human AChE
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Acetylcholinesterase (CHEMBL220)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

A computational view on the significance of E-ring in binding of (+)-arisugacin A to acetylcholinesterase.
Al-Rashid ZF, Hsung RP.
Bioorg Med Chem Lett (2015) 25 : 4848 -4853
PubMed 26159481 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 7.56 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL283509 2 9.00
CHEMBL3632858 1 8.17
CHEMBL24686 TERRITREM B 1 8.12
CHEMBL278342 1 7.59
CHEMBL3632852 1 5.60
CHEMBL3632853 1 5.46
CHEMBL3632857 1 -
CHEMBL3632856 1 -
CHEMBL3632855 1 -
CHEMBL3632854 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL283509 IC50 = 1.0 nM 9.00
CHEMBL283509 IC50 = 1.0 nM 9.00
CHEMBL3632858 IC50 = 6.8 nM 8.17
CHEMBL24686 TERRITREM B IC50 = 7.6 nM 8.12
CHEMBL278342 IC50 = 25.8 nM 7.59
CHEMBL3632852 IC50 = 2500.0 nM 5.60
CHEMBL3632853 IC50 = 3500.0 nM 5.46
CHEMBL3632857 IC50 > 100000.0 nM -
CHEMBL3632856 IC50 > 100000.0 nM -
CHEMBL3632855 IC50 > 100000.0 nM -
CHEMBL3632854 IC50 > 100000.0 nM -