Assay Detail
Binding
CHEMBL3635776
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human plasmatic BChE using butyrylthiocholine as substrate preincubated for 5 mins followed by substrate addition measured every 2 mins by Ellman's method
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.48 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3632988 | — | — | 1 | 7.70 |
| CHEMBL3410951 | — | — | 1 | 7.22 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.10 |
| CHEMBL3632987 | — | — | 1 | 7.10 |
| CHEMBL3410952 | — | — | 1 | 7.10 |
| CHEMBL3632990 | — | — | 1 | 7.05 |
| CHEMBL3632991 | — | — | 1 | 6.89 |
| CHEMBL3410955 | — | — | 1 | 6.89 |
| CHEMBL3410956 | — | — | 1 | 6.80 |
| CHEMBL3410954 | — | — | 1 | 6.72 |
| CHEMBL3632626 | — | — | 1 | 6.54 |
| CHEMBL3632992 | — | — | 1 | 6.40 |
| CHEMBL3632848 | — | — | 1 | 6.40 |
| CHEMBL3632994 | — | — | 1 | 6.27 |
| CHEMBL3410953 | — | — | 1 | 6.25 |
| CHEMBL3632847 | — | — | 1 | 6.21 |
| CHEMBL3632850 | — | — | 1 | 6.16 |
| CHEMBL3632993 | — | — | 1 | 6.16 |
| CHEMBL3632849 | — | — | 1 | 6.16 |
| CHEMBL3632989 | — | — | 1 | 6.11 |
| CHEMBL3632846 | — | — | 1 | 5.89 |
| CHEMBL3632851 | — | — | 1 | 5.82 |
| CHEMBL292314 | — | — | 1 | 5.75 |
| CHEMBL1256415 | — | — | 1 | 4.75 |
| CHEMBL153 | TROLOX | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3632988 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3410951 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL95 | TACRINE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3632987 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3410952 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3632990 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3632991 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3410955 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3410956 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3410954 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3632626 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3632992 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3632848 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3632994 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3410953 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL3632847 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL3632850 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3632993 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3632849 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3632989 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL3632846 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3632851 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL292314 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL1256415 | — | IC50 | = | 17560.0 | nM | 4.75 |
| CHEMBL153 | TROLOX | IC50 | > | 1000000.0 | nM | - |