Assay Detail
Binding
CHEMBL3636740
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Pim1 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 mins
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-1 (CHEMBL2147) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 39 | 8.71 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3634783 | — | — | 1 | 11.00 |
| CHEMBL3634760 | — | — | 1 | 10.89 |
| CHEMBL3634769 | — | — | 1 | 10.82 |
| CHEMBL3634767 | — | — | 1 | 10.70 |
| CHEMBL3634772 | — | — | 1 | 10.68 |
| CHEMBL3634771 | — | — | 1 | 10.66 |
| CHEMBL3634757 | — | — | 1 | 10.46 |
| CHEMBL3634770 | — | — | 1 | 10.44 |
| CHEMBL3634781 | — | — | 1 | 10.40 |
| CHEMBL3634782 | — | — | 1 | 10.39 |
| CHEMBL3634758 | — | — | 1 | 10.22 |
| CHEMBL3634761 | — | — | 1 | 10.14 |
| CHEMBL3634779 | — | — | 1 | 10.00 |
| CHEMBL3634756 | — | — | 1 | 9.85 |
| CHEMBL3634768 | — | — | 1 | 9.66 |
| CHEMBL3634755 | — | — | 1 | 9.57 |
| CHEMBL3634780 | — | — | 1 | 9.52 |
| CHEMBL3634759 | — | — | 1 | 9.41 |
| CHEMBL3634773 | — | — | 1 | 8.74 |
| CHEMBL3634775 | — | — | 1 | 8.70 |
| CHEMBL3634765 | — | — | 1 | 8.48 |
| CHEMBL3634777 | — | — | 1 | 8.47 |
| CHEMBL3634763 | — | — | 1 | 8.40 |
| CHEMBL3634778 | — | — | 1 | 8.22 |
| CHEMBL3634766 | — | — | 1 | 8.11 |
| CHEMBL3634762 | — | — | 1 | 8.07 |
| CHEMBL3634790 | — | — | 1 | 8.00 |
| CHEMBL3634791 | — | — | 1 | 8.00 |
| CHEMBL3634764 | — | — | 1 | 7.89 |
| CHEMBL3634793 | — | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3634783 | — | Ki | = | 0.01 | nM | 11.00 |
| CHEMBL3634760 | — | Ki | = | 0.013 | nM | 10.89 |
| CHEMBL3634769 | — | Ki | = | 0.015 | nM | 10.82 |
| CHEMBL3634767 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL3634772 | — | Ki | = | 0.021 | nM | 10.68 |
| CHEMBL3634771 | — | Ki | = | 0.022 | nM | 10.66 |
| CHEMBL3634757 | — | Ki | = | 0.035 | nM | 10.46 |
| CHEMBL3634770 | — | Ki | = | 0.036 | nM | 10.44 |
| CHEMBL3634781 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL3634782 | — | Ki | = | 0.041 | nM | 10.39 |
| CHEMBL3634758 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL3634761 | — | Ki | = | 0.073 | nM | 10.14 |
| CHEMBL3634779 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL3634756 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL3634768 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL3634755 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL3634780 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL3634759 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL3634773 | — | Ki | = | 1.82 | nM | 8.74 |
| CHEMBL3634775 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL3634765 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL3634777 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL3634763 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL3634778 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL3634766 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL3634762 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL3634790 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL3634791 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL3634764 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL3634793 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL3634776 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL3634774 | — | Ki | = | 171.0 | nM | 6.77 |
| CHEMBL3634786 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL3634788 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL3634787 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL3634784 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL3634789 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL3634785 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL3634792 | — | Ki | = | 3500.0 | nM | 5.46 |