Compound Detail
CHEMBL3634786
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Basic Information
| ChEMBL ID | CHEMBL3634786 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UQUBWQXJXQJXPB-UHFFFAOYSA-N |
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
210.2
MW (Da)
2.33
ALogP
3
HBA
1
HBD
54.5
PSA (Ų)
0.67
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 5 meas. best 6.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | Ki | 6.72 | 6.7133 | 190.0 | 3 |
| Serine/threonine-protein kinase pim-3 CHEMBL5407 | Ki | 6.52 | 6.52 | 300.0 | 1 |
| Serine/threonine-protein kinase pim-2 CHEMBL4523 | Ki | 6.1 | 6.1 | 800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 | Ki | = | 190.0 | nM | 6.72 | PIM Kinase Binding Activity Assay: PIM-1, PIM-2, and PIM-3 enzymes were generate... | - |
| Serine/threonine-protein kinase pim-1 | Ki | = | 190.0 | nM | 6.72 | PIM Kinase Binding Activity Assay: PIM-1, PIM-2, and PIM-3 enzymes were generate... | - |
| Serine/threonine-protein kinase pim-1 | Ki | = | 200.0 | nM | 6.7 | Inhibition of Pim1 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after... | 26459208 |
| Serine/threonine-protein kinase pim-3 | Ki | = | 300.0 | nM | 6.52 | Inhibition of Pim3 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after... | 26459208 |
| Serine/threonine-protein kinase pim-2 | Ki | = | 800.0 | nM | 6.1 | Inhibition of Pim2 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after... | 26459208 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26459208 | 10.1016/j.bmcl.2015.09.052 | Serine/threonine-protein kinase pim-1 | 1 |
| 26459208 | 10.1016/j.bmcl.2015.09.052 | Serine/threonine-protein kinase pim-2 | 1 |
| 26459208 | 10.1016/j.bmcl.2015.09.052 | Serine/threonine-protein kinase pim-3 | 1 |
Data from ChEMBL 36 via Core Engine