Assay Detail
Functional
CHEMBL3637523
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Antitrypanosomal activity against bloodstream trypomastigote forms of Trypanosoma brucei rhodesiense STIB 900 assessed as inhibition of growth
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
3-Nitrotriazole-based piperazides as potent antitrypanosomal agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.14 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.05 |
| CHEMBL3633321 | — | — | 1 | 6.64 |
| CHEMBL3633320 | — | — | 1 | 5.86 |
| CHEMBL3633322 | — | — | 1 | 5.47 |
| CHEMBL3633313 | — | — | 1 | 5.38 |
| CHEMBL3633312 | — | — | 1 | 5.35 |
| CHEMBL3633314 | — | — | 1 | 5.00 |
| CHEMBL3633316 | — | — | 1 | 4.95 |
| CHEMBL3633324 | — | — | 1 | 4.90 |
| CHEMBL3633328 | — | — | 1 | 4.89 |
| CHEMBL3633315 | — | — | 1 | 4.79 |
| CHEMBL3633317 | — | — | 1 | 4.71 |
| CHEMBL3633326 | — | — | 1 | 4.61 |
| CHEMBL3633325 | — | — | 1 | 4.58 |
| CHEMBL3633327 | — | — | 1 | 4.58 |
| CHEMBL3633318 | — | — | 1 | 4.48 |
| CHEMBL3633311 | — | — | 1 | 4.13 |
| CHEMBL3633323 | — | — | 1 | 4.07 |
| CHEMBL3633319 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3633321 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL3633320 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL3633322 | — | IC50 | = | 3410.0 | nM | 5.47 |
| CHEMBL3633313 | — | IC50 | = | 4219.0 | nM | 5.38 |
| CHEMBL3633312 | — | IC50 | = | 4478.0 | nM | 5.35 |
| CHEMBL3633314 | — | IC50 | = | 9909.0 | nM | 5.00 |
| CHEMBL3633316 | — | IC50 | = | 11260.0 | nM | 4.95 |
| CHEMBL3633324 | — | IC50 | = | 12610.0 | nM | 4.90 |
| CHEMBL3633328 | — | IC50 | = | 12790.0 | nM | 4.89 |
| CHEMBL3633315 | — | IC50 | = | 16360.0 | nM | 4.79 |
| CHEMBL3633317 | — | IC50 | = | 19270.0 | nM | 4.71 |
| CHEMBL3633326 | — | IC50 | = | 24600.0 | nM | 4.61 |
| CHEMBL3633325 | — | IC50 | = | 25996.0 | nM | 4.58 |
| CHEMBL3633327 | — | IC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL3633318 | — | IC50 | = | 33400.0 | nM | 4.48 |
| CHEMBL3633311 | — | IC50 | = | 74320.0 | nM | 4.13 |
| CHEMBL3633323 | — | IC50 | = | 85160.0 | nM | 4.07 |
| CHEMBL3633319 | — | IC50 | = | 156620.0 | nM | - |